Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABA(A) receptors

Neuroactive steroids (NASs) are synthesized within the brain and exert profound effects on behavior. These effects are primarily believed to arise from the activities of NASs as positive allosteric modulators (PAMs) of the GABA-type A receptor (GABA(A)R). NASs also activate a family of G protein–cou...

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Vydáno v:J Biol Chem
Hlavní autoři: Parakala, Manasa L., Zhang, Yihui, Modgil, Amit, Chadchankar, Jayashree, Vien, Thuy N., Ackley, Michael A., Doherty, James J., Davies, Paul A., Moss, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690684/
https://ncbi.nlm.nih.gov/pubmed/31239352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008875
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