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Homologous recombination defects and how they affect replication fork maintenance
Homologous recombination (HR) repairs DNA double strand breaks (DSBs) and stabilizes replication forks (RFs). RAD51 is the recombinase for the HR pathway. To preserve genomic integrity, RAD51 forms a filament on the 3′ end of a DSB and on a single-stranded DNA (ssDNA) gap. But unregulated HR results...
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| Publié dans: | AIMS Genet |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
AIMS Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6690234/ https://ncbi.nlm.nih.gov/pubmed/31435521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3934/genet.2018.4.192 |
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