An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism

Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting for ∼1.3 million deaths in 2017. As part of the immune response to Mtb infection, macrophages produce metabolites with the purpose of inhibi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Hua, Fedorov, Alexander A., Fedorov, Elena V., Hunt, Debbie M., Rodgers, Angela, Douglas, Holly L., Garza-Garcia, Acely, Bonanno, Jeffrey B., Almo, Steven C., de Carvalho, Luiz Pedro Sório
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689899/
https://ncbi.nlm.nih.gov/pubmed/31320588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906606116
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