Vanishing white matter: deregulated integrated stress response as therapy target

OBJECTIVE: Vanishing white matter (VWM) is a fatal, stress‐sensitive leukodystrophy that mainly affects children and is currently without treatment. VWM is caused by recessive mutations in eukaryotic initiation factor 2B (eIF2B) that is crucial for initiation of mRNA translation and its regulation d...

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Опубликовано в: :Ann Clin Transl Neurol
Главные авторы: Abbink, Truus E. M., Wisse, Lisanne E., Jaku, Ermelinda, Thiecke, Michiel J., Voltolini‐González, Daniel, Fritsen, Hein, Bobeldijk, Sander, ter Braak, Timo J., Polder, Emiel, Postma, Nienke L., Bugiani, Marianna, Struijs, Eduard A., Verheijen, Mark, Straat, Nina, van der Sluis, Sophie, Thomas, Adri A. M., Molenaar, Douwe, van der Knaap, Marjo S.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689685/
https://ncbi.nlm.nih.gov/pubmed/31402619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.50826
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