Vanishing white matter: deregulated integrated stress response as therapy target

OBJECTIVE: Vanishing white matter (VWM) is a fatal, stress‐sensitive leukodystrophy that mainly affects children and is currently without treatment. VWM is caused by recessive mutations in eukaryotic initiation factor 2B (eIF2B) that is crucial for initiation of mRNA translation and its regulation d...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Abbink, Truus E. M., Wisse, Lisanne E., Jaku, Ermelinda, Thiecke, Michiel J., Voltolini‐González, Daniel, Fritsen, Hein, Bobeldijk, Sander, ter Braak, Timo J., Polder, Emiel, Postma, Nienke L., Bugiani, Marianna, Struijs, Eduard A., Verheijen, Mark, Straat, Nina, van der Sluis, Sophie, Thomas, Adri A. M., Molenaar, Douwe, van der Knaap, Marjo S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689685/
https://ncbi.nlm.nih.gov/pubmed/31402619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.50826
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