The primacy of NF1 loss as the driver of tumorigenesis in neurofibromatosis type 1-associated plexiform neurofibromas

Neurofibromatosis type 1 (NF1) is a common tumor-predisposition disorder due to germline mutations in the tumor suppressor gene NF1 A virtually pathognomonic finding of NF1 is the plexiform neurofibroma (PN), a benign, likely congenital tumor that arises from bi-allelic inactivation of NF1 PN can un...

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Vydáno v:Oncogene
Hlavní autoři: Pemov, A, Li, H, Patidar, R, Hansen, NF, Sindiri, S, Hartley, SW, Wei, JS, Elkahloun, A, Chandrasekharappa, SC, Boland, JF, Bass, S, Mullikin, JC, Khan, J, Widemann, BC, Wallace, MR, Stewart, DR
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689395/
https://ncbi.nlm.nih.gov/pubmed/28068329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.464
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