Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway

BACKGROUND: During osteoporosis, bone mesenchymal stem cells (BMSCs) lineage commitment shifts to adipocytes, causing fat accumulation and bone loss in the skeleton. Seeking drugs that could reverse the adipocyte fate determination of BMSCs is critical for osteoporosis therapy. As a traditional Chin...

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Publicat a:Drug Des Devel Ther
Autors principals: Zhou, Xinying, Liu, Zezheng, Huang, Bin, Yan, Huibo, Yang, Changsheng, Li, Qingchu, Jin, Dadi
Format: Artigo
Idioma:Inglês
Publicat: Dove 2019
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689118/
https://ncbi.nlm.nih.gov/pubmed/31496649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S208458
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