Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway

BACKGROUND: During osteoporosis, bone mesenchymal stem cells (BMSCs) lineage commitment shifts to adipocytes, causing fat accumulation and bone loss in the skeleton. Seeking drugs that could reverse the adipocyte fate determination of BMSCs is critical for osteoporosis therapy. As a traditional Chin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Drug Des Devel Ther
Auteurs principaux: Zhou, Xinying, Liu, Zezheng, Huang, Bin, Yan, Huibo, Yang, Changsheng, Li, Qingchu, Jin, Dadi
Format: Artigo
Langue:Inglês
Publié: Dove 2019
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689118/
https://ncbi.nlm.nih.gov/pubmed/31496649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S208458
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