Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway

BACKGROUND: During osteoporosis, bone mesenchymal stem cells (BMSCs) lineage commitment shifts to adipocytes, causing fat accumulation and bone loss in the skeleton. Seeking drugs that could reverse the adipocyte fate determination of BMSCs is critical for osteoporosis therapy. As a traditional Chin...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Zhou, Xinying, Liu, Zezheng, Huang, Bin, Yan, Huibo, Yang, Changsheng, Li, Qingchu, Jin, Dadi
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689118/
https://ncbi.nlm.nih.gov/pubmed/31496649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S208458
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