MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

Coordinated regulation of the lysosomal and autophagic systems ensures basal catabolism and normal cell physiology, and failure of either system causes disease. Here we describe an epigenetic rheostat orchestrated by c-MYC and histone deacetylases that inhibits lysosomal and autophagic biogenesis by...

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Vydáno v:Nat Commun
Hlavní autoři: Annunziata, Ida, van de Vlekkert, Diantha, Wolf, Elmar, Finkelstein, David, Neale, Geoffrey, Machado, Eda, Mosca, Rosario, Campos, Yvan, Tillman, Heather, Roussel, Martine F., Andrew Weesner, Jason, Ellen Fremuth, Leigh, Qiu, Xiaohui, Han, Min-Joon, Grosveld, Gerard C., d’Azzo, Alessandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689058/
https://ncbi.nlm.nih.gov/pubmed/31399583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11568-0
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