MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

Coordinated regulation of the lysosomal and autophagic systems ensures basal catabolism and normal cell physiology, and failure of either system causes disease. Here we describe an epigenetic rheostat orchestrated by c-MYC and histone deacetylases that inhibits lysosomal and autophagic biogenesis by...

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Publicat a:Nat Commun
Autors principals: Annunziata, Ida, van de Vlekkert, Diantha, Wolf, Elmar, Finkelstein, David, Neale, Geoffrey, Machado, Eda, Mosca, Rosario, Campos, Yvan, Tillman, Heather, Roussel, Martine F., Andrew Weesner, Jason, Ellen Fremuth, Leigh, Qiu, Xiaohui, Han, Min-Joon, Grosveld, Gerard C., d’Azzo, Alessandra
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689058/
https://ncbi.nlm.nih.gov/pubmed/31399583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11568-0
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