Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels

Mast cells are effector cells that induce allergic inflammation by secreting inflammatory mediators. Gomisin M2 (G.M2) is a lignan isolated from Schisandra chinensis (Turcz). Baill. exhibiting anti-cancer activities. We aimed to investigate the anti-allergic effects and the underlying mechanism of G...

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Publicado en:Front Pharmacol
Autores principales: Dhakal, Hima, Lee, Soyoung, Kim, Eun-Nam, Choi, Jin Kyeong, Kim, Min-Jong, Kang, Jinjoo, Choi, Young-Ae, Baek, Moon-Chang, Lee, Byungheon, Lee, Hyun-Shik, Shin, Tae-Yong, Jeong, Gil-Saeng, Kim, Sang-Hyun
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688163/
https://ncbi.nlm.nih.gov/pubmed/31427975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00869
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