Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation

Plexiform neurofibroma (PN) tumors are a hallmark manifestation of neurofibromatosis type 1 (NF1) that arise in the Schwann cell (SC) lineage. NF1 is a common heritable cancer predisposition syndrome caused by germline mutations in the NF1 tumor suppressor, which encodes a GTPase-activating protein...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Rhodes, Steven D, He, Yongzheng, Smith, Abbi, Jiang, Li, Lu, Qingbo, Mund, Julie, Li, Xiaohong, Bessler, Waylan, Qian, Shaomin, Dyer, William, Sandusky, George E, Horvai, Andrew E, Armstrong, Amy E, Clapp, D Wade
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687955/
https://ncbi.nlm.nih.gov/pubmed/31091306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz095
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