FMRP Modulates Neural Differentiation through m(6)A-Dependent mRNA Nuclear Export

N(6)-methyladenosine (m(6)A) modification of mRNA is emerging as a vital mechanism regulating RNA function. Here, we show that fragile X mental retardation protein (FMRP) reads m(6)A to promote nuclear export of methylated mRNA targets during neural differentiation. Fmr1 knockout (KO) mice show dela...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Edens, Brittany M., Vissers, Caroline, Su, Jing, Arumugam, Saravanan, Xu, Zhaofa, Shi, Han, Miller, Nimrod, Rojas Ringeling, Francisca, Ming, Guo-li, He, Chuan, Song, Hongjun, Ma, Yongchao C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687293/
https://ncbi.nlm.nih.gov/pubmed/31340148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.072
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