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FMRP Modulates Neural Differentiation through m(6)A-Dependent mRNA Nuclear Export
N(6)-methyladenosine (m(6)A) modification of mRNA is emerging as a vital mechanism regulating RNA function. Here, we show that fragile X mental retardation protein (FMRP) reads m(6)A to promote nuclear export of methylated mRNA targets during neural differentiation. Fmr1 knockout (KO) mice show dela...
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| Опубликовано в: : | Cell Rep |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6687293/ https://ncbi.nlm.nih.gov/pubmed/31340148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.072 |
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