Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study

BACKGROUND: Additional forms of pre-exposure prophylaxis are needed to prevent HIV-1 infection. 3BNC117 and 10–1074 are broadly neutralizing anti-HIV-1 antibodies that target non-overlapping epitopes on the HIV-1 envelope. We investigated the safety, tolerability, pharmacokinetics, and immunogenicit...

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Udgivet i:PLoS One
Main Authors: Cohen, Yehuda Z., Butler, Allison L., Millard, Katrina, Witmer-Pack, Maggi, Levin, Rebeka, Unson-O’Brien, Cecilia, Patel, Roshni, Shimeliovich, Irina, Lorenzi, Julio C. C., Horowitz, Jill, Walsh, Stephen R., Lin, Shu, Weiner, Joshua A., Tse, Anna, Sato, Alicia, Bennett, Chelsey, Mayer, Bryan, Seaton, Kelly E., Yates, Nicole L., Baden, Lindsey R., deCamp, Allan C., Ackerman, Margaret E., Seaman, Michael S., Tomaras, Georgia D., Nussenzweig, Michel C., Caskey, Marina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687118/
https://ncbi.nlm.nih.gov/pubmed/31393868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219142
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