Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity

Por Kerwin, Bruce A., Bennett, Chelsey, Brodsky, Yan, Clark, Rutilio, Floyd, J. Alaina, Gillespie, Alison, Mayer, Bryan T., McClure, Megan, Siska, Christine, Seaman, Michael S., Seaton, Kelly E., Shaver, Jeremy, Tomaras, Georgia D., Yates, Nicole L., Ketchem, Randal R.
Publicado no J Pharm Sci (2020)

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study

Por Cohen, Yehuda Z., Butler, Allison L., Millard, Katrina, Witmer-Pack, Maggi, Levin, Rebeka, Unson-O’Brien, Cecilia, Patel, Roshni, Shimeliovich, Irina, Lorenzi, Julio C. C., Horowitz, Jill, Walsh, Stephen R., Lin, Shu, Weiner, Joshua A., Tse, Anna, Sato, Alicia, Bennett, Chelsey, Mayer, Bryan, Seaton, Kelly E., Yates, Nicole L., Baden, Lindsey R., deCamp, Allan C., Ackerman, Margaret E., Seaman, Michael S., Tomaras, Georgia D., Nussenzweig, Michel C., Caskey, Marina
Publicado no PLoS One (2019)