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Effects of Refolding on Large-Scale RNA Structure

Understanding RNA-mediated functions requires detailed characterization of the underlying RNA structure. In many cases, structure probing experiments are performed on RNA that has been “refolded” in some way, which may cause the conformation to differ from the native RNA. We used SHAPE-MaP to probe...

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Publié dans:Biochemistry
Auteurs principaux: Dethoff, Elizabeth A., Weeks, Kevin M.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687061/
https://ncbi.nlm.nih.gov/pubmed/31268687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01219
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