Effectiveness of addition of sirolimus to cyclosporine and mycophenolate mofetil-based graft-versus-host disease prophylaxis after unrelated nonmyeloablative hematopoietic cell transplantation: A multicentre phase III randomized trial

BACKGROUND: Acute graft-versus-host-disease (aGVHD) after nonmyeloablative human leukocyte antigen (HLA)-matched unrelated donor allogeneic hematopoietic cell transplantation (HCT) is associated with considerable morbidity and mortality. The trial evaluated the efficacy of adding sirolimus to cyclos...

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Publicat a:Lancet Haematol
Autors principals: Sandmaier, Brenda M., Kornblit, Brian, Storer, Barry E., Olesen, Gitte, Maris, Michael B., Langston, Amelia A., Gutman, Jonathan A., Petersen, Soeren L., Chauncey, Thomas R., Bethge, Wolfgang A., Pulsipher, Michael A., Woolfrey, Ann E., Mielcarek, Marco, Martin, Paul J., Appelbaum, Fred R., Flowers, Mary E.D., Maloney, David G., Storb, Rainer
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686903/
https://ncbi.nlm.nih.gov/pubmed/31248843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2352-3026(19)30088-2
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