Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats

BACKGROUND: The adipose afferent reflex (AAR), a sympatho-excitatory reflex, can promote the elevation of sympathetic nerve activity (SNA) and blood pressure (BP). Inflammation in the paraventricular nucleus (PVN) involves sympathetic abnormality in some cardiovascular diseases such as hypertension....

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Bibliographische Detailangaben
Veröffentlicht in:J Transl Med
Hauptverfasser: Ding, Lei, Kang, Ying, Dai, Hang-Bing, Wang, Fang-Zheng, Zhou, Hong, Gao, Qing, Xiong, Xiao-Qing, Zhang, Feng, Song, Tian-Run, Yuan, Yan, Liu, Ming, Zhu, Guo-Qing, Zhou, Ye-Bo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686415/
https://ncbi.nlm.nih.gov/pubmed/31391086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-2006-0
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