CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of cardiopulmonary units. No cure is currently available due to an incomplete understanding of vascular remodeling. Here we identify CD146-hypoxia-inducible transcription factor 1 alpha (HIF-1α) cross-regulation as a key determin...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Luo, Yongting, Teng, Xiao, Zhang, Lingling, Chen, Jianan, Liu, Zheng, Chen, Xuehui, Zhao, Shuai, Yang, Sai, Feng, Jing, Yan, Xiyun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686016/
https://ncbi.nlm.nih.gov/pubmed/31391533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11500-6
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