Therapeutic PD-L1 antibodies are more effective than PD-1 antibodies in blocking PD-1/PD-L1 signaling

Inhibitors of PD-1 signaling have revolutionized cancer therapy. PD-1 and PD-L1 antibodies have been approved for the treatment of cancer. To date, therapeutic PD-1 inhibitors have not been compared in a functional assay. We used an efficient T cell reporter platform to evaluate the efficacy of five...

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Udgivet i:Sci Rep
Main Authors: De Sousa Linhares, Annika, Battin, Claire, Jutz, Sabrina, Leitner, Judith, Hafner, Christine, Tobias, Joshua, Wiedermann, Ursula, Kundi, Michael, Zlabinger, Gerhard J., Grabmeier-Pfistershammer, Katharina, Steinberger, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685986/
https://ncbi.nlm.nih.gov/pubmed/31391510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47910-1
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