Spectrum of activity testing for therapeutics against all four dengue virus serotypes in AG129 mouse models: Proof-of-concept studies with the adenosine nucleoside inhibitor NITD-008.

Dengue is a mosquito-borne disease of global public health importance caused by four genetically and serologically related viruses (DENV-1 to DENV-4). Efforts to develop effective vaccines and therapeutics for dengue have been slowed by the paucity of preclinical models that mimic human disease. DEN...

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Publicat a:Antiviral Res
Autors principals: Milligan, Gregg N., White, Mellodee, Zavala, Diana, Pyles, Richard B., Sarathy, Vanessa V., Barrett, Alan D.T., Bourne, Nigel
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685202/
https://ncbi.nlm.nih.gov/pubmed/29665374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2018.04.012
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