Combined therapy with atorvastatin and atorvastatin-pretreated mesenchymal stem cells enhances cardiac performance after acute myocardial infarction by activating SDF-1/CXCR4 axis

The SDF-1/CXCR4 signaling plays a critical role in the trafficking of mesenchymal stem cells (MSCs) to the sites of tissue damage. Our recent study demonstrated that atorvastatin (ATV) treatment improved the survival of MSCs, and ATV pretreated MSCs ((ATV-)MSCs) exhibited enhanced engraftment to inj...

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Pubblicato in:Am J Transl Res
Autori principali: Tian, Xia-Qiu, Yang, Yue-Jin, Li, Qing, Xu, Jun, Huang, Pei-Sen, Xiong, Yu-Yan, Li, Xiang-Dong, Jin, Chen, Qi, Kang, Jiang, Lei-Pei, Chen, Gui-Hao, Qian, Li, Liu, Jiandong, Geng, Yong-Jian
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684913/
https://ncbi.nlm.nih.gov/pubmed/31396330
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