Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson’s disease (PD). Recently, P2X7 imaging has become possible with [(11)C]JNJ-(54173)717. We investigated P2X7 availability, in comparison with avai...

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Bibliografiske detaljer
Udgivet i:Front Neurosci
Main Authors: Crabbé, Melissa, Van der Perren, Anke, Bollaerts, Ilse, Kounelis, Savannah, Baekelandt, Veerle, Bormans, Guy, Casteels, Cindy, Moons, Lieve, Van Laere, Koen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684733/
https://ncbi.nlm.nih.gov/pubmed/31417352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00799
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