TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging

Tonicity-responsive enhancer binding protein (TonEBP or NFAT5) is a regulator of cellular adaptation to hypertonicity, macrophage activation and T-cell development. Here we report that TonEBP is an epigenetic regulator of thermogenesis and obesity. In mouse subcutaneous adipocytes, TonEBP expression...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Lee, Hwan Hee, An, Seung Min, Ye, Byeong Jin, Lee, Jun Ho, Yoo, Eun Jin, Jeong, Gyu Won, Kang, Hyun Je, Alfadda, Assim A., Lim, Sun Woo, Park, Jiyoung, Lee-Kwon, Whaseon, Kim, Jae Bum, Choi, Soo Youn, Kwon, Hyug Moo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684655/
https://ncbi.nlm.nih.gov/pubmed/31387996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11302-w
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