Combination Treatment with an Antibody–Drug Conjugate (A1mcMMAF) Targeting the Oncofetal Glycoprotein 5T4 and Carboplatin Improves Survival in a Xenograft Model of Ovarian Cancer

BACKGROUND: Recurrence occurs in over 75% of women with epithelial ovarian cancer despite optimal treatment. Selectively killing tumour cells thought to initiate relapse using an antibody–drug conjugate could prolong progression-free survival and offer an improved side-effect profile. A1mcMMAF is an...

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Publicat a:Target Oncol
Autors principals: Wan, Y. Louise, Sapra, Puja, Bolton, James, Chua, Jia Xin, Durrant, Lindy G., Stern, Peter L.
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2019
Matèries:
Original Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684567/
https://ncbi.nlm.nih.gov/pubmed/31332693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-019-00650-8
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