A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation

BACKGROUND: Diabetic nephropathy (DN) is a lethal diabetic microvascular complication characterized by chronic low-grade inflammation. The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome is implicated in the progression of DN. MCC950 is a selective and potent inhibitor of NL...

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Vydáno v:Diabetes Metab Syndr Obes
Hlavní autoři: Zhang, CongXiao, Zhu, XinWang, Li, LuLu, Ma, TianKui, Shi, Mai, Yang, Ying, Fan, QiuLing
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2019
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684489/
https://ncbi.nlm.nih.gov/pubmed/31447572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S199802
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