Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens

New antibiotics that are active against multi-drug-resistant strains and difficult-to-treat bacterial infections are needed. Synthetic modification of spectinomycin, a bacterial protein synthesis inhibitor, has been shown to increase antibacterial activity compared with spectinomycin. Aminomethyl sp...

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Veröffentlicht in:J Antibiot (Tokyo)
Hauptverfasser: Scarff, Jennifer M., Waidyarachchi, Samanthi L., Meyer, Christopher J., Lane, Douglas J., Chai, Weirui, Lemmon, Margaret M., Liu, Jiuyu, Butler, Michelle M., Bowlin, Terry L., Lee, Richard E., Panchal, Rekha G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684479/
https://ncbi.nlm.nih.gov/pubmed/31164713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41429-019-0194-8
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