Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity

Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we perform...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Lan, Jianfeng, Rollins, Jarod A., Zang, Xiao, Wu, Di, Zou, Lina, Wang, Zi, Ye, Chang, Wu, Zixing, Kapahi, Pankaj, Rogers, Aric N., Chen, Di
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684276/
https://ncbi.nlm.nih.gov/pubmed/31340143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.078
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