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Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span
Sirt1, a member of the sirtuin gene family, encodes the most conserved mammalian NAD(+)-dependent deacetylase enzyme responsible for removing acetyl groups from many proteins. The Sirt1 gene is known as a longevity gene whose knockout in mice leads to decreased lifespan relative to the wild type. Th...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6684063/ https://ncbi.nlm.nih.gov/pubmed/31386694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220581 |
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