Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells

Mono-methylindoles (MMI) were described as agonists and/or antagonists of the human aryl hydrocarbon receptor (AhR). Here, we investigated the effects of MMI on AhR-CYP1A pathway in human hepatocytes and HepaRG cells derived from human progenitor hepatic cells. All MMI, except of 2-methylindole, str...

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Gepubliceerd in:Toxicol Lett
Hoofdauteurs: Vyhlídalová, Barbora, Poulíková, Karolína, Bartoňková, Iveta, Krasulová, Kristýna, Vančo, Jan, Trávníček, Zdeněk, Mani, Sridhar, Dvořák, Zdeněk
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684055/
https://ncbi.nlm.nih.gov/pubmed/31201936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2019.06.004
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