Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle

Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle. Here, myosin II inhibition rescues rupture and partially rescues the DNA damage marker γH2AX, but an apparent block in cell cyc...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Main Authors: Xia, Yuntao, Pfeifer, Charlotte R., Zhu, Kuangzheng, Irianto, Jerome, Liu, Dazhen, Pannell, Kalia, Chen, Emily J., Dooling, Lawrence J., Tobin, Michael P., Wang, Mai, Ivanovska, Irena L., Smith, Lucas R., Greenberg, Roger A., Discher, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683732/
https://ncbi.nlm.nih.gov/pubmed/31239284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201811100
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