Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential

BACKGROUND: The differentiation of corneal limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) has great power as a novel treatment for ocular surface reconstruction and for modeling corneal epithelial renewal. However, the lack of profound understanding of the true LSC population ide...

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Dettagli Bibliografici
Pubblicato in:Stem Cell Res Ther
Autori principali: Vattulainen, Meri, Ilmarinen, Tanja, Koivusalo, Laura, Viiri, Keijo, Hongisto, Heidi, Skottman, Heli
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683518/
https://ncbi.nlm.nih.gov/pubmed/31383008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1354-2
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