Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer

BACKGROUND: The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a synergistic anti-tumor effect with conventional chemotherapy agents. In this st...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Nam, Ki Hong, Yi, Sang Ah, Nam, Gibeom, Noh, Jae Sung, Park, Jong Woo, Lee, Min Gyu, Park, Jee Hun, Oh, Hwamok, Lee, Jieun, Lee, Kang Ro, Park, Hyun-Ju, Lee, Jaecheol, Han, Jeung-Whan
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683399/
https://ncbi.nlm.nih.gov/pubmed/31387554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5997-2
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