Targeting HIF-1α in Combination with PPARα Activation and Postnatal Factors Promotes the Metabolic Maturation of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

Immature phenotypes of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) limit the utility of these cells in clinical application and basic research. During cardiac development, postnatal cardiomyocytes experience high oxygen tension along with a concomitant downregulation...

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Dades bibliogràfiques
Publicat a:J Mol Cell Cardiol
Autors principals: Gentillon, Cinsley, Li, Dong, Duan, Meixue, Yu, Wen-Mei, Preininger, Marcela K., Jha, Rajneesh, Rampoldi, Antonio, Saraf, Anita, Gibson, Gregory C., Qu, Cheng-Kui, Brown, Lou Ann, Xu, Chunhui
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683286/
https://ncbi.nlm.nih.gov/pubmed/31082397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.05.003
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