An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice

Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis due to M. tuberculosis (Mtb), which kills millions of people each year. BCG variably protects children, but not adults against tuberculosis. BCG evades phagosome maturation, autophagy, and reduces MHC-II expression of antigen-p...

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Dades bibliogràfiques
Publicat a:NPJ Vaccines
Autors principals: Khan, Arshad, Bakhru, Pearl, Saikolappan, Sankaralingam, Das, Kishore, Soudani, Emily, Singh, Christopher R., Estrella, Jaymie L., Zhang, Dekai, Pasare, Chandrashekhar, Ma, Yue, Sun, Jianjun, Wang, Jin, Hunter, Robert L., Tony Eissa, N., Dhandayuthapani, Subramanian, Jagannath, Chinnaswamy
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683161/
https://ncbi.nlm.nih.gov/pubmed/31396406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-019-0122-8
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