Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson’s Disease-Associated SH-SY5Y Cell Model

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. In this study, we explored the neuroprotective effect and underlying molecular mechanism of vasicinone against paraquat-induced cellular apoptosis in SH-SY5Y cells. Vasicinone reduced the paraquat-induced loss of cell viab...

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Publicat a:Nutrients
Autors principals: Ju, Da-Tong, Sivalingam, Kalaiselvi, Kuo, Wei-Wen, Ho, Tsung-Jung, Chang, Ruey-Lin, Chung, Li-Chin, Day, Cecilia Hsuan, Viswanadha, Vijaya Padma, Liao, Po-Hsiang, Huang, Chih-Yang
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682869/
https://ncbi.nlm.nih.gov/pubmed/31331066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu11071655
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