Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson’s Disease Associated α-Synuclein Levels

Mitochondrial dysfunction and disturbed mitochondrial dynamics were found to be common phenomena in the pathogenesis of Parkinson’s disease (PD). Vasicinone is a quinazoline alkaloid from <i>Adhatoda</i><i> </i><i>vasica</i>. Here, we investigated the autophagy/mi...

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Bibliographic Details
Main Authors: Chih-Yang Huang, Kalaiselvi Sivalingam, Marthandam Asokan Shibu, Po-Hsiang Liao, Tsung-Jung Ho, Wei-Wen Kuo, Ray-Jade Chen, Cecilia-Hsuan Day, Vijaya Padma Viswanadha, Da-Tong Ju
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-06-01
Series:Nutrients
Subjects:
Parkinson’s disease
vasicinone
paraquat
α-synuclein
mitophagy
reactive oxygen species
Online Access:https://www.mdpi.com/2072-6643/12/6/1707
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