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Ribonucleoside-5′-diphosphates (NDPs) support RNA polymerase transcription, suggesting NDPs may have been substrates for primordial nucleic acid biosynthesis

A better understanding of the structural basis for the preferences of RNA and DNA polymerases for nucleoside-5′-triphosphates (NTPs) could help define the catalytic mechanisms for nucleotidyl transfer during RNA and DNA synthesis and the origin of primordial nucleic acid biosynthesis. We show here t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gottesman, Max E., Mustaev, Arkady
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682740/
https://ncbi.nlm.nih.gov/pubmed/31189650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009074
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