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Inorganic phosphate, arsenate, and vanadate enhance exonuclease transcript cleavage by RNA polymerase by 2000-fold
Inorganic P(i) is involved in all major biochemical pathways. Here we describe a previously unreported activity of P(i). We show that P(i) and its structural mimics, vanadate and arsenate, enhance nascent transcript cleavage by RNA polymerase (RNAP). They engage an Mg(2+) ion in catalysis and activa...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5856549/ https://ncbi.nlm.nih.gov/pubmed/29483274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720370115 |
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