Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging

We examined the contribution of N-methyl-D-aspartate receptor (NMDAR) subunits in the redox-mediated decline in NMDAR function during aging. GluN2A and GluN2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged animals, indicating that a shift in diheteromeric G...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Kumar, Ashok, Thinschmidt, Jeffrey S., Foster, Thomas C.
Format: Artigo
Language:Inglês
Published: Impact Journals 2019
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682512/
https://ncbi.nlm.nih.gov/pubmed/31339863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102108
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