A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

Overproduction of reactive oxygen species (ROS) is known to mediate glutamate excitotoxicity in neurological diseases. However, how ROS burdens can influence neural circuit integrity remains unclear. Here, we investigate the impact of excitotoxicity induced by depletion of Drosophila Eaat1, an astro...

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Vydáno v:eLife
Hlavní autoři: Peng, Jhan-Jie, Lin, Shih-Han, Liu, Yu-Tzu, Lin, Hsin-Chieh, Li, Tsai-Ning, Yao, Chi-Kuang
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682402/
https://ncbi.nlm.nih.gov/pubmed/31318331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47372
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