Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: Potential therapeutic application for treatment of gliomas

We tested the herbal extract 2,3,5,6-tetramethylpyrazine (TMP) for possible therapeutic efficacy against a glioma cell line and against gliomas transplanted into rat brains. In the cultured glioma cells, 50 μM TMP significantly inhibited glutamate-induced increase in intracellular calcium. Significa...

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Huvudupphovsmän: Fu, Yu-Show, Lin, Yen-Yang, Chou, Shih-Chich, Tsai, Tung-Hu, Kao, Lung-Sen, Hsu, Shao-Yun, Cheng, Fu-Chou, Shih, Yang-Hsin, Cheng, Henrich, Fu, Yu-Yi, Wang, Jia-Yi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Duke University Press 2008
Ämnen:
Basic and Translational Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613816/
https://ncbi.nlm.nih.gov/pubmed/18314418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2007-051
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