Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

We identified a locus on mouse chromosome 10 that accounts for 60% of the genetic variance in methamphetamine intake in mice selectively bred for high versus low methamphetamine consumption. We nominated the trace amine-associated receptor 1 gene, Taar1, as the strongest candidate and identified reg...

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Sparad:
Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Stafford, Alexandra M, Reed, Cheryl, Baba, Harue, Walter, Nicole AR, Mootz, John RK, Williams, Robert W, Neve, Kim A, Fedorov, Lev M, Janowsky, Aaron J, Phillips, Tamara J
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2019
Ämnen:
Genetics and Genomics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682400/
https://ncbi.nlm.nih.gov/pubmed/31274109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46472
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