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The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage
The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1(Col2) mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular mediators of canonical TGFβ signaling. However,...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6681752/ https://ncbi.nlm.nih.gov/pubmed/31311865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902927116 |
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