T-cell TGF-β signaling abrogation restricts medulloblastoma progression

Cancer cell secretion of TGF-β is a potent mechanism for immune evasion. However, little is known about how central nervous system tumors guard against immune eradication. We sought to determine the impact of T-cell TGF-β signaling blockade on progression of medulloblastoma (MB), the most common ped...

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Main Authors: Gate, David, Danielpour, Moise, Rodriguez, Javier, Kim, Gi-Bum, Levy, Rachelle, Bannykh, Serguei, Breunig, Joshua J., Kaech, Susan M., Flavell, Richard A., Town, Terrence
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143044/
https://ncbi.nlm.nih.gov/pubmed/25082897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412489111
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