IFI16 targets the transcription factor Sp1 to suppress HIV-1 transcription and latency reactivation

The interferon γ-inducible protein 16 (IFI16) is known as immune sensor of retroviral DNA intermediates. We show that IFI16 restricts HIV-1 independently of immune sensing by binding and inhibiting host transcription factor Sp1 that drives viral gene expression. This antiretroviral activity and abil...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Host Microbe
Main Authors: Hotter, Dominik, Bosso, Matteo, Jønsson, Kasper L., Krapp, Christian, Stürzel, Christina M., Das, Atze, Littwitz-Salomon, Elisabeth, Berkhout, Ben, Russ, Alina, Wittmann, Sabine, Gramberg, Thomas, Zheng, Yue, Martins, Laura J., Planelles, Vicente, Jakobsen, Martin R., Hahn, Beatrice H., Dittmer, Ulf, Sauter, Daniel, Kirchhoff, Frank
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681451/
https://ncbi.nlm.nih.gov/pubmed/31175045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.05.002
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker