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Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation

RATIONALE: Transforming Growth Factor (TGF)-β is critically involved in myocardial injury, repair and fibrosis, activating both Smad-dependent and non-Smad pathways. The in vivo role of TGF–β signaling in regulation of macrophage function is poorly understood. We hypothesized that in the infarcted m...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Chen, Bijun, Huang, Shuaibo, Su, Ya, Wu, Yi-Jin, Hanna, Anis, Brickshawana, Adipong, Graff, Jonathan, Frangogiannis, Nikolaos G
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681442/
https://ncbi.nlm.nih.gov/pubmed/31092129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315069
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