Concentration Effects in the Interaction of Monoclonal Antibodies (mAbs) with their Immediate Environment Characterized by EPR Spectroscopy

Monoclonal antibodies (mAbs) are often needed and applied in high concentration solutions, >100 mg/mL. Due to close intermolecular distances between mAbs at high concentrations (~10–20 nm at 200 mg/mL), intermolecular interactions between mAbs and mAbs and solvent/co-solute molecules become non-n...

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Udgivet i:Molecules
Main Authors: Haeri, Haleh H., Blaffert, Jacob, Schöffmann, Florian A., Blech, Michaela, Hartl, Josef, Garidel, Patrick, Hinderberger, Dariush
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680867/
https://ncbi.nlm.nih.gov/pubmed/31295948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24142528
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