Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

Gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) are overexpressed in most prostate cancers. GRPR expression is higher in early stages while PSMA expression increases with progression. The possibility of targeting both markers with a single theranostics radiotr...

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Publicado en:Pharmaceutics
Main Authors: Abouzayed, Ayman, Yim, Cheng-Bin, Mitran, Bogdan, Rinne, Sara S., Tolmachev, Vladimir, Larhed, Mats, Rosenström, Ulrika, Orlova, Anna
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680768/
https://ncbi.nlm.nih.gov/pubmed/31340483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11070358
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