The Biological Effects of Double-Dose Alpha-1 Antitrypsin Augmentation Therapy. A Pilot Clinical Trial

Rationale: Augmentation therapy with intravenous AAT (alpha-1 antitrypsin) is the only specific therapy for individuals with pulmonary disease from AAT deficiency (AATD). The recommended standard dose (SD; 60 mg/kg/wk) elevates AAT trough serum levels to around 50% of normal; however, outside of slo...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Campos, Michael A., Geraghty, Patrick, Holt, Gregory, Mendes, Eliana, Newby, Paul R., Ma, Shuren, Luna-Diaz, Landy V., Turino, Gerard M., Stockley, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680306/
https://ncbi.nlm.nih.gov/pubmed/30965011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201901-0010OC
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