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An Expedient Total Synthesis of Chivosazole F: an Actin‐Binding Antimitotic Macrolide from the Myxobacterium Sorangium Cellulosum

A unified strategy for the chemical synthesis of the chivosazoles is described. This strategy is based on two closely related approaches involving the late‐stage installation of the isomerization‐prone (2Z,4E,6Z,8E)‐tetraenoate motif, and an expedient fragment‐assembly procedure. The result is a hig...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Williams, Simon, Jin, Jialu, Kan, S. B. Jennifer, Li, Mungyuen, Gibson, Lisa J., Paterson, Ian
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680201/
https://ncbi.nlm.nih.gov/pubmed/27897365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201610636
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